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Biopharmaceutics And Pharmacokinetics Book By Brahmankar Pdf Downloadgolkes


Biopharmaceutics and Pharmacokinetics: A Treatise by Brahmankar and Jaiswal




Biopharmaceutics and pharmacokinetics are two interrelated disciplines that deal with the fate of drugs in the body. Biopharmaceutics studies the factors influencing the rate and extent of drug absorption, while pharmacokinetics describes the mathematical relationships between the drug concentration in the body and the time. Together, they help to optimize the therapeutic efficacy of drug products by designing appropriate dosage forms, dosing regimens, and drug delivery systems.




biopharmaceutics and pharmacokinetics book by brahmankar pdf downloadgolkes


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One of the most comprehensive and authoritative books on this subject is Biopharmaceutics and Pharmacokinetics: A Treatise by D.M. Brahmankar and Sunil B. Jaiswal. This book covers the basic concepts, principles, and applications of biopharmaceutics and pharmacokinetics in a clear and systematic manner. It also includes numerous examples, problems, case studies, and references to facilitate learning and understanding.


Contents of the Book




The book consists of 12 chapters, which are as follows:


  • Chapter 1: Introduction: This chapter introduces the scope, objectives, and importance of biopharmaceutics and pharmacokinetics. It also defines some basic terms and concepts used in these fields.



  • Chapter 2: Absorption of Drugs: This chapter discusses the factors affecting the absorption of drugs from different routes of administration, such as oral, parenteral, topical, transdermal, pulmonary, nasal, ocular, etc. It also explains the mechanisms and models of drug absorption, such as passive diffusion, facilitated diffusion, active transport, pinocytosis, etc.



  • Chapter 3: Distribution of Drugs: This chapter describes the processes involved in the distribution of drugs between blood and various tissues and organs. It also covers the factors influencing drug distribution, such as blood flow, tissue binding, plasma protein binding, etc. It also introduces the concepts of apparent volume of distribution, tissue-to-plasma partition coefficients, etc.



  • Chapter 4: Protein Binding of Drugs: This chapter elaborates on the phenomenon of protein binding of drugs in plasma and tissues. It explains the types, mechanisms, and consequences of protein binding. It also discusses the methods of measuring protein binding and its effects on drug pharmacokinetics.



  • Chapter 5: Elimination of Drugs: This chapter deals with the processes involved in the elimination of drugs from the body. It covers the two major routes of drug elimination, namely metabolism (biotransformation) and excretion (renal or biliary). It also explains the factors affecting drug metabolism and excretion, such as enzyme induction or inhibition, genetic polymorphism, age, disease, etc.



  • Chapter 6: Compartment Models: This chapter introduces the concept of compartment models to describe the pharmacokinetics of drugs in the body. It explains the assumptions, advantages, and limitations of compartment models. It also covers the different types of compartment models, such as one-compartment model, two-compartment model, multi-compartment model, etc.



  • Chapter 7: Pharmacokinetic Parameters: This chapter defines and calculates various pharmacokinetic parameters that characterize the disposition of drugs in the body. These parameters include clearance, volume of distribution, half-life, area under the curve (AUC), mean residence time (MRT), bioavailability (F), etc.



  • Chapter 8: Nonlinear Pharmacokinetics: This chapter discusses the situations where the pharmacokinetics of drugs deviate from linearity. It explains the causes and consequences of nonlinear pharmacokinetics. It also covers some examples of nonlinear pharmacokinetic phenomena, such as saturation kinetics (Michaelis-Menten kinetics), autoinduction or autoinhibition kinetics, enzyme inhibition kinetics, etc.



  • Chapter 9: Bioavailability and Bioequivalence: This chapter deals with the concepts of bioavailability and bioequivalence of drug products. It defines bioavailability as the rate and extent of drug absorption from a dosage form into systemic circulation. It defines bioequivalence as the similarity in bioavailability between two drug products that are pharmaceutically equivalent or alternative. It also discusses the methods of measuring bioavailability and bioequivalence, such as single-dose studies, multiple-dose studies, crossover studies, parallel studies, etc.



  • Chapter 10: Pharmacokinetics of Clinical Situations: This chapter applies the principles of pharmacokinetics to various clinical situations, such as renal or hepatic impairment, pregnancy, lactation, pediatrics, geriatrics, obesity, etc. It also covers the pharmacokinetics of drug interactions, such as pharmacokinetic synergism or antagonism, displacement interactions, enzyme induction or inhibition interactions, etc.



  • Chapter 11: Multiple Dosage Regimens: This chapter explains the design and evaluation of multiple dosage regimens of drugs. It covers the concepts of steady state, loading dose, maintenance dose, dosing interval, etc. It also discusses the methods of adjusting dosage regimens based on pharmacokinetic parameters, such as clearance, volume of distribution, half-life, etc.



  • Chapter 12: Controlled Release Drug Delivery Systems: This chapter describes the various types of controlled release drug delivery systems that aim to modify the release rate and/or site of drug delivery. It covers the advantages, disadvantages, and applications of controlled release drug delivery systems. It also explains the mechanisms and kinetics of drug release from different types of controlled release drug delivery systems, such as matrix systems, reservoir systems, osmotic systems, etc.



Conclusion




Biopharmaceutics and Pharmacokinetics: A Treatise by Brahmankar and Jaiswal is a comprehensive and authoritative book that covers the basic and advanced aspects of biopharmaceutics and pharmacokinetics. It is suitable for students, teachers, researchers, and practitioners in the fields of pharmacy, medicine, pharmacology, and related disciplines. It is also a valuable reference for anyone interested in learning more about the fate and effects of drugs in the body.


References




: Biopharmaceutics and Pharmacokinetics: A Treatise by D.M. Brahmankar and Sunil B. Jaiswal. Vallabh Prakashan, 2005.




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